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The abundance of each protein was constrained from mass spectrometry data and a normalized time course of phosphorylation data was used as the input for pattern search algorithm (a global optimization technique) to fit the model to the totality of the gathered hepatocyte or HCC-specific data

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Macas M, Garca-Cortes A, Torres M, Ancizu-Marckert J, Pascual JI, Dez-caballero F, et al

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