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A meta-analysis by Su et al 120 found that the GSTM1 null polymorphism is significantly associated with an increased risk of coronary artery disease in both the overall and mixed populations

131 It had been reported that natural compounds Artesunate, 113 Saponin Formosanin C, 114 and Arsenite 132 can induce ferroptosis by promoting ferritin phagocytosis

Additionally, sterigmatocystin (STG), a toxic biosynthetic precursor of aflatoxins, can be found in infested materials

Semin Hematol 26:105113 Williams RJP (1982) Free manganese(II) and iron(II) cations can act as intracellular cell controls

However, whether a common or different mechanism triggers the decreased expression of GSTA1 requires further investigation, although reports have shown that this is related to the conversion of GSTA1 allele 52A to 52G, which prevents transcription factor (Sp 1) binding to the promoter site [43]

Many studies highlight potential benefits in improving insulin sensitivity, glucose metabolism, and lipid profiles, but inconsistencies in dosing, study duration, and methodology limit definitive conclusions