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Several large trials, such as the Carotene and Retinol Efficacy Trial (CARET), results from the National Health and Nutritional Examination Survey (NHAES), the Third National Health and Nutrition Examination Survey (NHANES III), and the Coronary Artery Risk Development in Young Adults (CARDIA) have demonstrated that serum carotenoid and retinol levels or dietary intakes are positively associated with lung function, while negatively associated with the incidence of COPD [172,173,174,175,176,177,178,179]

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Immunofluorescence tissues were mounted with Immuno-Mount (Thermo Fisher, 9990402) and coverslipped for imaging

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