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The criteria for liver injury were vacuolization of hepatocytes and pyknotic hepatocyte nuclei, activation of Kupffer cells and enlargement of sinusoids

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Whenever cortisol levels are low, the hypothalamus releases a hormone called CRH ( corticotrophin-releasing hormone ), which directs the pituitary gland to release yet another hormone, ACTH ( adrenocorticotropic hormone )

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Analysis of intercellular interactions revealed an increased number of interactions between cells and other endocrine cell types in GCGR-KO islets compared to WT islets (Fig