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Collectively, these results suggested that APR-017 and LCS3 treatment induce vulnerability of VRK2-deficient PC cells by GSH inhibition and consequent disruption of the balance between ROS generation and antioxidation

For example, MYC and KRAS overexpression are involved in diverse metabolic changes, including increased glucose uptake and rewiring of GSH biosynthesis [10, 11]

[DOI] [PubMed] [Google Scholar] 28.Vallee B.L
