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Am J Physiol 258:L308L312 Westin MA, Hunt MC, Alexson SE (2005) The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes
However, it was not until 1919 that the first pathological evidence was obtained by Trtiakoff who provided a description of significant neuromelanin loss in SNc neurons and the presence of Lewy bodies (LBs) [33], cytoplasmatic structures previously reported by Frederic Lewy in PD-affected brains [34]
Variables such as age, sex, environmental factors, dietary habits, circadian cycle, contribute to the complexity of successfully translating preclinical findings into precise personalized clinical care

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
one current focus is a turbocharger of mitochondrial energy production and its importance for immunology and the brain

Duester G, Farres J, Felder MR, Holmes RS, Hoog JO, Pares X, et al