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Second, standardization of bioactive content remains difficult due to significant batch variation resulting from differences in geographical origin and processing methods, necessitating development of robust quality fingerprinting and regulatory standards (117, 118)

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second, CIH upregulates PSPC1, further activating the TGF--Smad pathway and driving the acquisition of EMT and cancer stem cell-like characteristics in lung cancer cells (Kim et al., 2020

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