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Semaglutide May Be Better If You: Want a medication with longer track record and more research Prefer having the option of pills instead of injections Have diabetes and need proven heart benefits Experience fewer side effects with single-hormone approach Semaglutide has proven cardiovascular benefits and can reduce the risk of heart attack and stroke in people with diabetes

The next step: Your doctor can help you decide if a small maintenance dose makes sense or if tapering off slowly is the better fit

Patients with severe kidney disease or end-stage renal disease may not be appropriate candidates for this therapy, particularly if they have significant fluid retention or are prone to dehydration