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p -values below 0.05 ( ), 0.01 (#), and 0.001 () were considered as significant

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However, the excess glucose concentration triggers aldose reductase resulting in depleted Nicotinamide adenine dinucleotide phosphate (NADPH) levels, a reducing equivalent and subsequently, accumulates osmotically active sorbitol [10,11,12]

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Library preparation and RNA sequencing was performed by Novogene

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