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Mechanism 1: Compete With NADPH Some research shows that Finasteride competes with the coenzyme NADPH

The FOXO4-DRI (DRI) peptide which specifically targets FOXO4-TP53 interaction [17] was included in the analysis as a positive control

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As some peptides modify cell growth or repair, there is a theoretical risk of encouraging undesired cell proliferation

An electrostatic scaffold for the design of newer GLP-1R agonists As mentioned above, the role of charge-charge interactions is only as important as 4.76% (2/42, Table 4 of supplementary file supps.pdf ) in the stabilization of the complex structure of GLP-1R ECD and semaglutide [24], including only two interfacial salt bridges (Table 1) and two interfacial hydrogen bonds (Table 2)