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Proc Natl Acad Sci USA , 2017, 114: 580585 Oliveira G, Wu CJ

In rare cases, serious side effects such as allergic reactions, rapid heartbeat, and chest pain have been reported

The Mediterranean diet exerts beneficial effects on glycaemic control, systemic inflammation and oxidative stress via several bioactive compounds such as polyphenols and omega-3 fatty acids as well as by promoting gut microbiota health and diversity

Nevertheless, it is essential to acknowledge the inherent limitations of this surgical approach, particularly concerning the rehabilitation and overall quality of life of elderly patients

Inhibiting macrophage-capping protein suppresses UFM1-mediated pirin modification, which downregulates GPX4 transcription and promotes HMGB1 cytosolic translocation, ultimately triggering ferroptosis and rapid release of this damage-associated molecular pattern (91)

All except one case were carriers of the same mutation, S467C.18 This is change of Serine to Cysteine at codon 467
