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Researchers have summarized strategies that can enhance the persistent responsiveness of CAR-T cells and improve their immune phenotype (85, 86)

It involves digesting proteins into peptides, separating them using liquid chromatography, and analyzing the resulting peptides with mass spectrometry

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CRISPR/Cas9-mediated targeting of ABCC1 in Cas9-expressing THP-1 cells using multiple sgRNAs re-sensitized them to BCL-2 inhibition, as ABCC1 -targeted cells were rapidly depleted upon Venetoclax treatment (Fig

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