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This raises the question whether a concomitant increased mitochondrial ROS production may even aggravate the situation in Nf1 Myf5 mice, potentially causing a vicious cycle

To provide protection against ROS, repair oxidative damage and maintain a reducing intracellular environment, (developing) red cells are equipped with a variety of antioxidants, including superoxide dismutase 1 and 2, catalase, glutathione peroxidase 1, peroxiredoxin I and II, and glutathione (GSH)-synthesizing enzymes (van Zwieten et al., 2014

Vegetarians and vegans lack dietary B12 sources unless they consume fortified foods

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For the identification of GSH adduct of compound, compound T13 (100 M) was reacted with GSH (1 mM) in DMSO for 1 h, and the reaction mixture was directly injected into LC-MS/MS for monitoring at 254 nm absorbance and MS ( m/z = 100-700, positive mode), and the unique product was identified from mass spectrum