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What the research shows about GLP-1 medications: According to a study published in the New England Journal of Medicine (STEP-1 trial), participants receiving once-weekly semaglutide 2.4 mg plus lifestyle intervention experienced a mean weight loss of 14.9% from baseline over 68 weeks, compared with 2.4% for placebo plus lifestyle intervention

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Individuals carrying certain alleles at this locus may require higher doses, alternative medications, or combination therapies to achieve the same weight loss as those with naturally responsive receptor variants

In direct terms: semaglutide reduces energy intake through appetite suppression

There are major programs from at least two pharmaceutical companies

And compared with the 2022 study, the participants of this earlier investigation gained weight back at a slower pace