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The empty stomach requirement matters because food presence affects gastric pH and transit time
- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)
Many of the binding processes in biologyof proteins to other proteins or to DNA or to drugs and metabolitesare driven predominantly by the degree to which nonpolar molecules tend to avoid solvation in water
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