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15 Although there exists considerable sequence similarity, the sensitivity of these two enzymes to their inhibitor malonyl-CoA differs greatly (CPTIA has a tenfold higher Ki for malonyl-CoA), 15 which makes CPTIA the more prevailing enzyme that accomplishes the rate-limiting step in -oxidation

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Both .raw and .mzML files have been deposited and can be downloaded from public metabolomics repository GNPS/MassIVE ( under the accession codes MSV000094216 (pVTA experiment) and MSV000094218 (in-vitro synthesis of salsolinol experiment)