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A number of researchers have reported that the activation of the SphK1/S1P signaling pathway marks the occurrence of autoimmune diseases, and the up-regulation of SphK1 is related to the pathogenesis of multiple sclerosis (Luo et al., 2017)

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The combination of edema with a local lesion may displace the brain in one or more directions

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Thus, group I included patients with cardiac arrhythmias and dyslipidemia, group II included patients with cardiac arrhythmia disorders but without dyslipidemia, and group III consisted of healthy subjects