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Precision becomes more critical here

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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

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And thus threatened the lucrative business market that big pharma had created

In short: while the studies suggest a vaguely positive trend, the design lacks rigour, and the conclusions are highly speculative