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Chem Biol Interact (2020) 324:109093

Most clinical studies suggest that daily doses of up to 2,000mg to 3,000mg are well-tolerated

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Neurturin has multiple neurotrophic effects on adult rat sacral parasympathetic ganglion neurons

Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA