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Additionally, efforts to enhance intrinsic neuronal protective mechanisms, through upregulation of neurotrophic factors, restoration of calcium homeostasis, or stabilization of synaptic plasticity, offer further promise [29, 30]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Mujica-Parodi L.R., Amgalan A., Sultan S.F., Antal B., Sun X., Skiena S., Lithen A., Adra N., Ratai E.-M., Weistuch C., et al

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doi: 10.1039/C6MB00600K 187 ArmstrongCWMcGregorNRLewisDPButtHLGooleyPR

In Szary syndrome (see Chapter 145), the tumor cells produce IL-5 and, therefore, are responsible for the eosinophilia, which is a reflection of tumor burden.64 Where eosinophilia is a good prognostic factor, eosinophils are considered to be part of an effective host response to the tumor.65,66 The specific nature of eosinophil-dependent antitumor activity has not been sufficiently explored but may include, in addition to direct cytotoxic effects on tumor cells, tumor antigen presentation, vascular compromise via microthrombi formation, or synergism with the antitumor response of other leukocytes