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The appearance of free hemoglobin in the blood has been linked to the development of brain malaria, which remains the most severe and difficult to treat complication of the disease [9]

Qin J, Wang H, Rets A, Harari S, Alexis H, Eid I, Pincus MR

De derde gaat ervan uit dat oxidatie van ethanol tot acetaldehyde en van acetaldehyde tot azijnzuur, gekatalyseerd door respectievelijk alcohol dehydrogenase en aldehyde dehydrogenase, leidt tot de productie van NADH en tot een toename van de vrije concentraties van NADH/NAD+ in de hepatocyten

Choice E: Stating that nothing can be done represents an ultimatum and an inappropriate threat of patient abandonment

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Unfortunately, the trial failed to meet its primary endpoint on PFS