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Options include chewing sugar-free gum, such as xylitol gum, which has been shown to reduce plaque acidity, promote saliva flow, and strengthen tooth enamel

Moreover, depletion of reduced glutathione by HOSCN could also lead to an increase in oxidative stress and bacterial susceptibility to neutrophil-generated oxidants [235, 236]

Conceptually, these pathways should be viewed not as isolated modules but as an integrated redox defense network, in which failure of one arm can be partially compensated by the others until a critical threshold of lipid peroxide accumulation is exceeded

Specifically, unique post-translational modifications that are incorporating either glycosylation and/or phosphorylation, can differentiate peripheral BDNF in terms of their bioactive and bio-stable properties, as shown through proteomics [163]

In a mice model with exclusive knockout of Gpx4 in the hematopoietic system, Altamura et al

Finally, astrocytes are fundamental for brain resilience and brain compensation through numerous neuroprotective systems (again glutamate clearance, K + buffering and ROS scavenging), through reactive astrogliosis, which protects the nervous tissue against acute lesions and limits chronic disorders 118 , and through supporting postlesional regeneration 119,120