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2ce), indicating that either DEG treatment for 6 h is insufficient to modify the OGDHc-E2, or that exogenous glutarate preferentially alters the PDHc, as previously reported 9
[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Grozio A

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Therefore, autophagy is not only an important regulatory factor in ferroptosis but also a protective mechanism in cells responding to iron overload and oxidative stress

This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse

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