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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

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Popat RA, Van Den Eeden SK, Tanner CM, et al

Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response

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