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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field
That is far weaker than a Phase 1 human trial
This is the gold-standard way to answer does the oral form actually get in. What they found: ~38.4% oral bioavailability, with a half-life around 6.9 hours oral and 3.8 hours IV
That stubborn fat that refuses to budge, no matter how disciplined your diet or dedicated your workouts
It engages binding sites with approximately ten times greater affinity than that of comparable NNMT inhibitors [2]
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