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Summary: B12 injections begin working at a cellular level immediately, though noticeable symptom improvement typically occurs within 4872 hours to several weeks depending on deficiency severity

Feb 2006;26(1):32-9

In a cohort study involving 8,067 patients with T2D who participated in the National Health and Nutrition Examination Survey, low and high serum vitamin B12 levels were associated with a higher risk of cardiovascular disease mortality [69]