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These RNS modify respiratory chain complexes I and IV through tyrosine nitration, disrupt inner membrane integrity via cardiolipin oxidation, and directly damage mtDNAeffects that amplify rather than merely parallel ROS-mediated injury ( 2+ homeostasis represents another critical vulnerability

IL-1 Induces MMP-9-dependent brain astrocytic migration via transactivation of PDGF receptor/NADPH oxidase 2-derived reactive oxygen species signals
Autophagy 14, 21732175

[71,72] confirmed that hypoxia increased mitochondrial ROS generation at Complex III, which led to the collection of HIF-1 protein, revealing that mitochondria-derived ROS were both required and sufficient to initiate HIF-1 stabilization during hypoxia

G.Requena-IbanezJ

Expression of adhesion molecules by human endothelial cells exposed to oxidized low density lipoprotein
