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If you are concerned about acne whilst taking B12 supplements, it is advisable to discuss this with your GP rather than discontinuing treatment without medical guidance, particularly if the B12 has been prescribed to address a documented deficiency

10.1016/0304-419x(96)00003-0 277

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ABSTRACT The half-life of a drug is most commonly defined as the time taken for the plasma or blood level of the drug to fall by half

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