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These symptoms are linked to degeneration in serotonergic and noradrenergic circuits, particularly in the raphe nuclei and locus coeruleus, and may manifest years before classical motor signs (Lee et al., 2022

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10.1016/S1474-4422(20)30231-3 CrossRef Google Scholar View reference in article 55 KhafagyE.-S.KameiN.NielsenE