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The presented results indicate, that in man, supplementation with high doses of antioxidants does not always ameliorate the oxidative stress component of various disease states of an organism or oxidative stress is not the only cause of the diseases

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Mol Carcinog 45:164174 Versantvoort C, Schuurhuis G, Pinedo H, Eekman C, Kuiper C, Lankelma J, Broxterman H (1993) Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells

Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood

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The hydrophobicity of a small molecular drug is a pivotal factor in its permeation across biological cell membranes