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doi: 10.1038/s41598-020-64711-z 124 FeugangJRodriguez-OsorioNKayaAWangHPageGOstermeierGet al

Biomolecules 10 (10), 1431

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Ferroptosis is involved in diabetes myocardial ischemia/reperfusion injury through endoplasmic reticulum stress

More accurate measurement of GSH concentrations and its flux across cell organelles and between tumor cells and their microenvironment will allow development of better tools for in silico exploration of therapeutic opportunities and deeper understanding of glutathiones many roles

Furthermore, stringent iron histochemistry together with transcriptomic analyses suggest that the AD brain contains a higher proportion of tightly bound/sequestered iron pools, and that anemialike and iron metabolism-related transcriptional changes emerge early, supporting a functional iron deficiency hypothesis