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These allergies sometimes affect their skin disease, but even when they dont they can affect the persons well-being
The therapeutic window for systemic iron chelation in FRDA is notoriously narrow
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-Synuclein (-Syn) binds Cu 2+ with high affinity via its N-terminal amine, the side chain of Asp2, and the imidazole group of His50, inducing conformational changes that modulate copper redox activity, reduce oxidative stress, and promote membrane recycling and SNARE-complex membrane fusion (172)
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