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Adding hemp seeds, flour, and proteins to bread production significantly improved the nutritional value of products, with significant increases in fiber and protein content [96]

These findings are supported by the results of an open multicentre study in more than 1000 patients with angina pectoris, which demonstrated that a reduction was obtained in the consumption of traditional antianginal drug therapies and the frequency of anginal attacks during the 12-month period of supplementation with oral l-carnitine 2g daily

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Likewise, metabolites accumulated after long term utilization of pharmacological therapies, such as valproate [79] and the antibiotic cefditoren pivoxil [80], can be conjugated to carnitine and result in carnitine depletion