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In this model, the reduced anti-tumor immunity of sleep-deprived animals was also indexed by the reduced number of antigen-presenting cells (dendritic cells) in the lymph nodes, as well as by the decreased effector CD4 T-cell numbers and corresponding cytokine profile (decreased IFN-), resulting in lowered Th1 response of Th cells, i.e., the most effective immune response against tumors

Animal studies show improved tensile strength, faster collagen formation, and better biomechanical outcomes in torn tendons and ligaments

These early changes reflect the peptides activation of lipolytic pathways and increased fat oxidation, though visible physical changes are not yet apparent

10.1111/nyas.13416 72 SuD.ZhaoY.WangB.XuH.LiW.ChenJ.et al (2011)

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