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Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

In turn, sleep deprivation leads to an upregulation of proapoptotic and proinflammatory markers such as the apoptotic chromatin condensation inducer 1 (Acin1), heat shock protein family E member 1 (HSPE1), and golgin subfamily A member 3 (GOLGA3), thus indicating an overall beneficial function of sleep for myelins maintenance and turnover (Vivo and Bellesi, 2019)

The enzymes governing this modificationby modulating MT charge, rigidity, and binding affinityrepresent promising therapeutic targets for neurodegenerative diseases, ciliopathies, and cancers (Table 1)

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