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Whereas, GPX3 overexpression could largely reverse the effect of RSL3 on activating ferroptosis via upregulating Nrf2 and GPX4

In mice treated with amoxicillin or ciprofloxacin, depletion of Lactobacillus reuteri (Firmicutes) led to reduced brain and serum GABA, downregulation of GABA-A receptors, and diminished 5-HT and DA, neurochemical changes that coincided with anxiety- and depression-like behaviors (Bibi et al., 2025)

Yu C, et al

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In this cloud, secondary ionization can occur through matrixanalyte or analyteanalyte interactions

These findings from animal models suggest that astrocytic lactate release may involve multiple pathways beyond monocarboxylate transporters, allowing adaptive responses to neuronal energy demands and pathological stress