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(A and N) Experimental scheme

Most patients begin with a weekly loading phase for 48 weeks, followed by monthly maintenance, with no downtime

Real-time cell analysis (RTCA) The xCELLigence RTCA system uses microelectronic biosensors to monitor real-time cellular events such as cell number change, adhesion, viability, morphology and motility 26

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Keywords: hyaluronic acid, CD44 receptor targeting, redox responsive, folic acid, micelles, doxorubicin Introduction In recent years, nanoparticles have been attracting increasing attention in cancer therapy and cancer diagnosis