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Studies performed by In addition, ISA also cause cytoprotective autophagy in melanoma and colorectal cancer, through repressing PI3K/Akt/mTOR signaling, besides its apoptosis-promoting effects, where excessive autophagy would lead to death of cancer cells (Li et al., 2022
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32 However, the discovery of levodopa (or other dopamine agonists) led to a shift away from surgical therapy to chronic pharmaceutical treatment

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