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During the mitochondrial life cycle, mitochondrial fission and fusion can regulate both the equilibrium of mitochondrial dynamics and mitochondrial biogenesis

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More than a century ago, patients would get worse and worse until they died

It stimulates lipolysis (the breakdown of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids), particularly in areas with stubborn fat deposits

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The clinical symptoms that result from this process include progressive muscle weakness, atrophy, speech and swallowing difficulties, as well as respiratory complications (Mejzini et al., 2019