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All these changes have been linked to the existence of a chronic detrimental low-grade inflammatory state in the adipose tissue (62)
Like many other protein kinases, the activity of mTORC2 relies heavily on its subcellular localization, especially to membranous structures, such as the plasma membrane, mitochondria, endosomes, ER (endoplasmic reticulum), and MAM [92]

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Karvelas Evangelos G
Khavinson VK, Razumovskii MI, Trofimova SV, Grigor'yan RA, Chaban TV, Oleinik TL
