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Both male and female mice treated with intranasal GHK-Cu had significantly lower concentrations of NFL-1 in the frontal cortex compared to intranasal saline treated cohorts (Figure 4C) indicating GHK-Cu was able to attenuate axonal damage associated with brain aging in C57BL/6 mice

This antioxidant effect also enhances the activity of direct-acting antivirals such as telaprevir, especially in telaprevir-resistant replicon cells ( Beyond HCV, PYC also modulates host factors implicated in viral replication and immune regulation, including long non-coding IFN-induced protein-44 (lnc-IFI-44), polycystic kidney disease 1-like 3 (Pkd1l3), and ubiquitin-specific peptidase 31 (Usp31) ( PYC has also been reported to inhibit HIV-1 entry and replication ( Importantly, PYCs antiviral activity extends beyond direct viral inhibition to include complementary host-directed effects

Mao S, Wang L, Zhao X, Guo L, Lin Q, Wang X, et al

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