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In epi-CblC, an epimutation leads to a splicing variant in the adjacent PRDX1 gene causes transcriptional silencing of MMACHC (Yu et al., 2013)

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It should be recognized that loss of FMRP or MeCP2 will affect a number of downstream targets which exist not only on neurons, but on glial cells and other tissues (McCauley et al., 2011

The catalytic VIII subregion of Raf interacts with MEK through its C-terminal catalytic domain, which phosphorylates serine residues, initiating MEK1/2 activation