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81874187 (AL))

Ween MP, Lokman NA, Hoffmann P, Rodgers RJ, Ricciardelli C, Oehler MK

When combining peptides, start with lower individual doses and increase gradually

G 0 flies were crossed to a white balancer and all white+ progeny were individually balanced

This position of Nrf2 for polyubiquitination by the Cul3-RBX-1 complex marks it for proteasomal degradation, maintaining a low level of Nrf2 under normal conditions

Flies are an attractive model system to test dietary interventions due to their short lifespan, genetic similarities with humans in fundamental metabolic pathways, and cost-effective maintenance (Eickelberg et al., 2022