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These may include better plasma membrane permeation, an improved ability to permeate the inner mitochondria membrane in both the protonated and deprotonated state and a more favourable lipid membrane partitioning of NMY1009, resulting in greater inner mitochondrial membrane accumulation and sustained release of NMY1009 into the mitochondrial matrix and intermembrane space

Manufactured to high purity standards and suitable for scientific investigation

Next, to determine if ABHD11 acted directly on the Lp glu adduct in an enzymatic manner, we measured the activity of purified ABHD11 against a recombinant Lp glu OGDHc-E2 peptide encompassing the minimal residues around the lipoylated K110 (Extended Data Fig

KLOW peptide is a synthetic research peptide utilized in controlled laboratory environments for scientific analysis and peptide-related studies