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The sam1/sam1 mutant cells likely exhibited decreased growth in this condition due to downregulated CDC21 expression (fold change of 0.62, p-value=0.0247), which encodes thymidylate synthase, and/or because RNR complex inhibition could create dNTP pool imbalances which in concert with less Cdc21 could cause more difficulty to interconvert between some deoxyribonucleotides in these mutant cells, thereby creating sensitivity to this condition (Fig 13)

Dolores Prez-Sala, [email protected] Present address: Tahl Zimmerman, North Carolina Agricultural and Technical State University, Greensboro, NC, United States This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The Hippo-YAP pathway in various cardiovascular diseases: focusing on the inflammatory response

There is an exchange of lactate between two different regions within the tumor microenvironment the hypoxic region and the normoxic region