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Such scientific questions should be evaluated within the perspective of the fetal-maternal interfaces (i.e., placenta and fetal membrane [fetal]-decidua [maternal]) as well as the BBB

(3) Low efficacy Although the autophagy inducers rapamycin and alginate and the autophagy inhibitor 3-methyladenine (3-MA) have been widely used in animal or cellular disease models (to treat liver diseases, neurodegenerative diseases, etc.) and have shown clear efficacy, they are not used in the clinic because of the high concentrations needed to induce their function [168]

In recent years, significant research has explored the use of probes in medical biology, particularly for acute kidney injury (AKI), a condition with high incidence and mortality rates

Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2

Cystine/Glutamate antiporter xCT controls skeletal muscle glutathione redox, bioenergetics and differentiation

Another cell line, i.e ., HT-22 cells of the hippocampus, was exposed to varying doses of -hydroxybutyric acid to investigate its neurotropic effects, OS markers, mitochondrial function, and apoptosis [Majrashi et al ., 2021]