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Sola Bhagwat, Sayona City Road, Gota, Ahmedabad-382481, GUJARAT, INDIA

The stopping boundaries for this futility rule were to terminate enrollment on the trial if the number of overall responses compared to the number of patients enrolled who were evaluated did not meet the requirements of Supplementary Table S12

Thus, GPx4 activity is a central molecular switch in the ferroptosis pathway, and the System XcGSH-GPx4 axis is also a central pathway in the ferroptosis pathway, in which a key member, inhibitory SLC7A11 (solute carrier family 7 member 11), inactivates GPx4 and increases lethal reactive oxygen species by blocking the entry of cysteine into the cell, thereby reducing GSH synthesis and ultimately inducing ferroptosis

& Villarroel-Espindola, F

It is a spectrum disorder characterized by recurrent seizures due to abnormal excessive and synchronous neuronal activity in the brain
