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Proc Natl Acad Sci USA 2014;111:186316

Related links DATABASES Glossary GGDEF domains Catalytic domains of diguanylate cyclases that are responsible for the condensation of two GTP molecules to cyclic di-GMP (c-di-GMP)
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However, rigorous human clinical trials are limited

This range serves as a general guideline, but adjustments may be necessary as therapy progresses

Consequently, finding ways to overcome the limited therapeutic effect imposed by the BBB has become a central goal in advancing delivery systems targeted to the brain
