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[7] [4] Neurological symptoms can occur even before anaemia develops and include paraesthesia (pins and needles) in the hands and feet, numbness, difficulty walking, and balance problems due to subacute combined degeneration of the spinal cord

Lipid-soluble compounds can presumably cross the enterocyte apical plasma membrane by diffusion with subsequent transfer through the enterocytes into the portal or lymphatic circulations

Harrel SK, Rees TD
