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Combination with SGLT2 inhibitors to augment the benefits of this drug class in HFrEF with, for example, the weight-lowering effects of GLP-1 RA could offer a clinically valuable and feasible option addressing the spectrum of abnormalities associated with this HF phenotype

In one study, microdosing GLP-1s supported moderate weight loss of up to 10 pounds over 40 weeks in participants. MICRODOSING GLP-1 BENEFITS Do More, Age Less Modulated inflammatory pathways in clinical trials. Studies found a reduced risk of cognitive decline Supported cardiovascular health in clinical trials Improved mitochondrial function and oxidative stress in clinical trials Low doses reduced side effects in clinical trials Supported moderate weight loss of up to 10 pounds over 40 weeks in one study *See studies cited below

And which one is better

Jankowski, J., Floege, J., Fliser, D., Bohm, M

[DOI] [PubMed] [Google Scholar] 56.Pharmacologic Approaches to Glycemic Treatment

GLP-1 and GIP drugs and their indications This chart shows GLP-1 and GIP drug class including route of administration, frequency and indications